The Indiana Rail Road (reporting mark INRD) is a United States Class III railroad,^[1] originally operating over former former Illinois Central Railroad trackage from Lis, Illinois to Indianapolis, Indiana, a distance of 155 miles (249 km). This line, now known as the Indiana Rail Road's Indianapolis Subdivision comprises most of the former IC line from Indianapolis to Effingham, Illinois; Illinois Central successor Canadian National Railway retains the portion from Lis to Effingham.

In June 2006, INRD completed the purchase of the Canadian Pacific Railway line from Terre Haute to Bedford, Indiana, the former Milwaukee Road/Soo Line Railroad Latta Subdivision, now known as INRD's Chicago Subdivision, which crosses the Indianapolis Subdivision at grade at Linton, Indiana. The former Latta Sub was isolated from the rest of the CPR, and was reached from Chicago via trackage rights over CSX Transportation's former Chicago and Eastern Illinois Railroad line; further trackage rights over CSX's former Monon from Bedford to Louisville, Kentucky (negotiated as part of the Monon's merger with CSX predecessor Louisville and Nashville Railroad in 1971) allowed the CPR access into the Bluegrass State. These trackage rights are now transferred to the Indiana Rail Road as part of the sale, bringing INRD's total route structure to approximately 500 miles. The company also operates the remnants of the Monon Railroad in and around Bloomington, Indiana, and has trackage rights over other lines in and around Indianapolis.

The INRD primarily hauls coal from Indiana mines to electric generating plants along the line. Appliances, grain, plastics, aggregates and food products are the other major freight hauled. Major customers include Indianapolis Power & Light, Ameren, Hoosier Energy, Duke Energy, Lincoland AgriEnergy (ethanol), Marathon Oil, Hershey Foods, General Electric, Mont Eagle Mills, PolyOne Corporation, Bemis Plastics and others.